How serious is intestinal metaplasia?

How serious is intestinal metaplasia?

Intestinal metaplasia can be severe. The transformation of the cells of the gastric lining puts a person at a much higher risk of developing gastric cancer. While it is not possible to avoid some risk factors such as genetics, people can avoid other risk factors, including diet, H. pylori infection, and smoking.

How often does intestinal metaplasia turn to cancer?

Atrophic gastritis, intestinal metaplasia, mild-moderate dysplasia, and severe dysplasia were associated with annual incidences of gastric cancer of 0.1%, 0.25%, 0.6%, and 6.0%, respectively.

What is gastritis with focal intestinal metaplasia?

Chronic gastritis has a high incidence in adults, causing progressive destruction of glandular structures, favoring the development of gastric atrophy. The association of chronic gastritis with intestinal type metaplasia of gastric mucosa has a poor outcome as intestinal metaplasia is regarded as a precancerous lesion.

Can focal intestinal metaplasia be reversed?

In the long term, with follow up of at least five years, there is epidemiological evidence that IM may be reversible although a combination of antioxidant agents and eradication of H pylori may be necessary to achieve this.

What causes gastric intestinal metaplasia?

Multiple risk factors have been associated with the development of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic factors, environmental milieu, rheumatologic disorders, diet, and intestinal microbiota.

What is focal gastric metaplasia?

Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with intestinal epithelium, and is associated with an increased risk of dysplasia and cancer.

What causes focal intestinal metaplasia?

What is intestinal metaplasia in the esophagus?

Intestinal metaplasia is a condition in which epithelial cells (the cells that line the stomach and esophagus) become altered or replaced by other cells, called goblet cells. Goblet cells are large, round, hollow cells that are normally found in the intestines; they should not reside in the stomach or esophagus.