Is rituximab Approved for membranous nephropathy?
In conclusion, rituximab was noninferior to cyclosporine in inducing proteinuria remission at 12 months and was superior in maintaining long-term proteinuria remission up to 24 months in patients with membranous nephropathy who were at high risk for progressive disease.
How does rituximab work in nephrotic syndrome?
Rituximab treatment leads to B cell depletion caused by B cell apoptosis, antibody-dependent cellular cytotoxicity or phagocytosis, suppressing interactions between B cells and T cells, which may prevent relapses in patients with nephrotic syndrome.
Does Rituxan affect the kidneys?
Kidney Problems: Especially if you are receiving Rituxan for non–Hodgkin’s lymphoma (NHL). Rituxan can cause severe kidney problems that lead to death. Your healthcare provider should do blood tests to check how well your kidneys are working.
What drugs can cause membranous nephropathy?
Examples of medications that can cause membranous nephropathy include nonsteroidal anti-inflammatory drugs and gold salts. Exposure to certain infections. Examples of infections that increase the risk of membranous nephropathy include hepatitis B, hepatitis C and syphilis.
What is the treatment for membranous nephropathy?
There is no specific treatment for membranous nephropathy. Supportive care with the use of diuretics and angiotensin-converting enzyme inhibitors in combination with angiotensin II receptor blocker is recommended, but these agents have only a limited effect.
Is membranous nephropathy the same as membranous glomerulonephritis?
Membranous glomerulonephritis (MGN) is a specific type of GN. MGN develops when inflammation of your kidney structures causes problems with the functioning of your kidney. MGN is known by other names, including extramembranous glomerulonephritis, membranous nephropathy, and nephritis.
Is rituximab good for nephrotic syndrome?
Rituximab was first reported to induce remission of nephrotic syndrome in a boy aged 16 years who was treated for co-existing idiopathic thrombocytopenic purpura. Since then, other studies have shown the efficacy of this agent in patients with difficult-to-treat steroid-dependent nephrotic syndrome (Table 1).
What are the long term side effects of rituximab?
Does Rituxan cause any long-term side effects?
- heart problems, such as heart attack or ventricular fibrillation (a type of abnormal heart rhythm)
- blockage or tearing of your intestines.
- kidney failure or other serious kidney problems.
- serious infections, such as shingles.
- reactivation of the hepatitis B virus*
What are the long-term side effects of rituximab?
How do you treat membranous nephropathy?
Is membranous nephropathy a disability?
Nephrotic syndrome is listed as a qualifying disability under the SSA’s Blue Book under Medical Listing 6.06. According to this listing, an individual must be suffering from nephrotic syndrome with anasarca and the condition must persist for at least three months despite prescribed treatments and therapy.