What are the main clinical symptoms of Alport syndrome?

What are the main clinical symptoms of Alport syndrome?

What are the signs and symptoms of Alport syndrome?

  • Blood in the urine (hematuria), the most common and earliest sign of Alport syndrome.
  • Protein in the urine (proteinuria)
  • High blood pressure (hypertension)
  • Swelling in the legs, ankle, feet, and around the eyes (called edema)

What is Alport syndrome life expectancy?

Prognosis. Women affected by Alport syndrome generally have a normal lifespan. Typically, the only symptom experienced by female patients is hematuria or the presence of blood in the urine. In extreme instances, elevated blood pressure, swelling, and hearing loss may arise as complications during pregnancy.

Can Alport syndrome be cured?

There is no cure for Alport syndrome, but there are treatments that can help protect your kidneys. Blood pressure medicines called angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) can help keep your kidneys working longer.

What is Alport kidney disease?

Alport syndrome is an inherited form of kidney inflammation (nephritis). It is caused by a defect (mutation) in a gene for a protein in the connective tissue, called collagen. The disorder is rare. There are three genetic types: X-linked Alport syndrome (XLAS) — This is the most common type.

At what age does Alport syndrome develop?

About 50% of untreated males with XLAS develop kidney failure by age 25, increasing to 90% by age 40 and nearly 100% by age 60. Females with XLAS usually do not develop kidney insufficiency until later in life. They may not develop kidney insufficiency or failure at all, but the risk increases as they grow older.

Is Alport syndrome a disability?

The syndrome is very similar in its symptoms to glomerulonephritis, but can also damage eyesight and hearing. Although having the disease alone is not yet sufficient to apply for disability benefits, the Alport Syndrome can debilitate those who have it and render them disabled.

Does Alport syndrome cause deafness?

People with Alport syndrome frequently develop sensorineural hearing loss, which is caused by abnormalities of the inner ear , during late childhood or early adolescence.

What is Alport syndrome?

Alport syndrome is a genetic condition characterized by kidney disease, hearing loss, and eye abnormalities. Most affected individuals experience progressive loss of kidney function, usually resulting in end-stage kidney disease.

What is the s2cid for alport syndrome?

S2CID 28650514. ^ “Alport syndrome”. Renal Unit at the Royal Infirmary of Edinburgh, Scotland. ^ “EdRen – Edinburgh Royal Infirmary Renal Unit – Alport anti-GBM disease”. www.edren.org. Retrieved 2016-02-17. ^ Tryggvason K, Heikkil√§ P, Pettersson E, Tibell A, Thorner P (May 1997). “Can Alport syndrome be treated by gene therapy?”.

What is the CID number for alport syndrome?

S2CID 28650514. ^ “Alport syndrome”. Renal Unit at the Royal Infirmary of Edinburgh, Scotland. ^ “EdRen – Edinburgh Royal Infirmary Renal Unit – Alport anti-GBM disease”. www.edren.org. Retrieved 2016-02-17. ^ Tryggvason K, Heikkil√§ P, Pettersson E, Tibell A, Thorner P (May 1997).