What does a high interleukin 2 mean?
The interleukin-2 receptor is a heterotrimeric transmembrane protein that is upregulated on activated T cells, and high sIL-2r levels are found in hemophagocytic syndromes, lymphoma, autoimmune lymphoproliferative syndrome, and other conditions associated with T-cell activation.
What is an interleukin 2 test for?
Interleukin-2 (IL-2) – IL-2 is a protein cytokine produced primarily by T-helper lymphocytes in response to infection. IL-2 signals T cell proliferation and antibody secretion by B cells. IL-2 therapy is approved for treatment of certain types of cancer and is being studied for treatment of other medical conditions.
What causes elevated IL-2?
The serum soluble interleukin 2 receptor (sIL2R) level is elevated in patients with most types of lymphoid neoplasms, and is also elevated in patients with solid tumors or reactive conditions, such as severe inflammation.
What autoimmune diseases does high levels interleukin 2 receptor effect soluble serum?
Our experience regarding serum soluble interleukin-2 receptor (sIL-2R) measurement as a marker of lymphocyte activation consists of patients with autoimmune disease: 37 with systemic lupus erythematosus (SLE), 23 with autoimmune hepatitis (AIH), 74 with inflammatory bowel disease and six with Wegener’s granulomatosis ( …
What is soluble interleukin?
Soluble interleukin-2 receptor (sIL-2R) is associated with cellular immune reactions and might therefore be increased in sarcoidosis. Its sensitivity is approximately 70% and higher in patients with parenchymal involvement.
What is soluble IL 2R?
The soluble interleukin-2 receptor (sIL-2R, sIL2R, sTAC, sCD25) is a reliable biomarker for disease activity in inflammatory disorders such as sarcoidosis.
Is HLH a terminal?
Familial-type HLH is usually fatal if not treated. Treatment for familial or persistent acquired HLH may include: Chemotherapy (cancer drugs) Immunotherapy (drugs that affect your immune system)
What is the treatment for HLH?
Treatment for familial or persistent acquired HLH may include: Chemotherapy (cancer drugs) Immunotherapy (drugs that affect your immune system) Steroids (drugs that fight inflammation)
How sensitive is sIL-2R in diagnosing human hepatocellular carcinoma (HLH)?
This is the first study to evaluate sensitivity and specificity of sIL-2r in diagnosing adult HLH. Our results confirm that sIL-2r is a sensitive test and should be used, as per the HLH-2004 diagnostic criteria, in combination with other diagnostic tests and clinical expertise to diagnose HLH.
What is the normal range of sil2r?
The evaluation of sIL2R levels (median, 2,685 U/ml) revealed that they had increased from the initial measurement (median, 1,156 U/ml), consistently with disease progression (P=0.0198). Diagnostic value of serum sIL2R level for the diagnosis of malignant lymphoma
Which lymphomas have the highest serum sil2r levels?
In the present study, aggressive lymphomas exhibited the highest serum sIL2R levels; however, indolent lymphomas exhibited a mild elevation, similar to other disease categories.
What is the significance of sil-2r/ferritin ratio in lymphoma-associated hemophagocytic syndrome?
A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary hemophagocytic lymphohistiocytosis (HLH), has a poor outcome.