Table of Contents
What is JAK1 gene?
JAK1 Gene – Janus Kinase 1 This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain.
What is the function of the JAK protein?
Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal transduction pathways that govern cellular survival, proliferation, differentiation and apoptosis. Evidence to date, indicates that JAK kinase function may integrate components of diverse signaling cascades.
What kind of protein is JAK?
JAKs are a family of proteins that belong to a category of intracellular non-receptor tyrosine kinases. In mammals, the JAK family contains four members: JAK1, JAK2, JAK3, and TYK2.
What do JAK inhibitors do?
If you have rheumatoid arthritis (RA), your doctor may suggest Janus kinase (JAK) inhibitors to help ease your joint pain and swelling. These drugs tamp down your overactive immune system — the body’s defense against germs — to help prevent damage to your joints.
What does JAK mean?
|Just Another Kinase (aka Janus Kinase)
|Journalists Association of Korea (South Korea)
|Japanese Association at Kearney (University of Nebraska, Kearney)
|Jazakom Allaho Khairan (Arabic: May Allah Reward You; Thank You)
What does the JAK pathway do?
The JAK/STAT pathway regulates embryonic development and is involved in the control of processes such as stem cell maintenance, haematopoiesis and the inflammatory response. The pathway transduces signals from cytokines, interleukins and growth factors that act through a number of transmembrane receptor families.
What is JAK in medical terms?
What do Janus kinases do?
The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in cell growth, survival, development, and differentiation of a variety of cells but are critically important for immune cells and hematopoietic cells.