What is mode of action of atorvastatin?

What is mode of action of atorvastatin?

Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

What is the function of statin medication?

Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.

How do statin drugs work to lower cholesterol?

Statin drugs lower LDL cholesterol by slowing down the liver’s production of cholesterol. They also increase the liver’s ability to remove LDL cholesterol that is already in the blood. The Food and Drug Administration (FDA) offers advice on the risks related to taking statins: Controlling Cholesterol with Statins.

Is atorvastatin an antiplatelet?

Recent studies demonstrated that atorvastatin possesses antiplatelet activity via inhibition of platelet formation of NADPH oxidase-derived ROS.

What is contraindication of atorvastatin?

Contraindications. Hypersensitivity to atorvastatin. Active liver disease or unexplained transaminase elevation. Your doctor should not prescribe this medication if you are a patient with liver problems. Women who are pregnant or breastfeeding should not take atorvastatin.

When are statins indicated?

This forms the basis of the ACC/AHA recommendations on statins for primary prevention—namely, that statins are indicated for patients between 40 and 75 years of age with diabetes, LDL greater than 190, or a 10-year ASCVD risk of greater than 7.5%.

Why do doctors push statins drugs?

Statins are the go-to treatment option for lowering cholesterol levels and risk of cardiovascular complications, like heart attack and stroke. Statins work by slowing down cholesterol production and enabling the liver to remove low-density lipoproteins (LDL), or “bad cholesterol,” from the bloodstream.

Do statins lower HDL?

Statin-induced increases in HDL cholesterol help to reduce atherosclerosis. Statin therapy greatly reduces LDL-cholesterol levels and slows progression of coronary atherosclerosis.

Is a statin an antithrombotic?

Statins possess a potentially unique antithrombotic mechanism that alters both coagulation and platelet activation, an ability that is not shared by the anticoagulant and antiplatelet drugs currently in use.

Is atorvastatin and clopidogrel the same?

Atorvastatin + Clopidogrel is a combination of two medicines: Atorvastatin and Clopidogrel, which prevents heart attack and stroke. Atorvastatin is a lipid-lowering medication that blocks an enzyme required in the body to make cholesterol.

What is the difference between atorvastatin and atorvastatin calcium?

Atorvastatin is a prescription medicine used to treat high cholesterol. It is marketed as a calcium salt under the brand name Lipitor (atorvastatin calcium), produced by Pfizer. It is also available as a generic medicine. Atorvastatin is one of the most popular medicines for treating high cholesterol.

What is the mechanism of action of statin?

increased incidence of lupus and pneumonia 15) – Note the similarity between “statin-induced lupus” and “ minocycline-induced lupus .” 16)

  • dyspnea ( pain while breathing) – Those with pulmonary involvement such as sarcoidosis patients sometimes confuse their disease symptoms with the side effects of statins.
  • muscle pain 17) 18)
  • What are the dangers of taking a statin?

    being sick

  • memory problems
  • hair loss
  • pins and needles
  • inflammation of the liver (hepatitis),which can cause flu-like symptoms
  • inflammation of the pancreas (pancreatitis),which can cause stomach pain
  • skin problems,such as acne or an itchy red rash
  • sexual problems,such as loss of libido (reduced sex drive) or erectile dysfunction
  • What are the side effects of statins?

    Statins cause far fewer side-effects than people believe, the world’s largest study has found. The cholesterol-busting drugs are taken by about eight million people in the UK to cut the chance of heart attack and stroke. But up to 80 per cent of those who

    What are the side effects of statin?

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