What is pathological calcification?

What is pathological calcification?

By definition, pathologic calcification refers to the deposition of calcium phosphates (CaP) or other calcific salts at sites, which would not normally have become mineralized. Abnormal accumulation can occur in areas of tissue damage (dystrophic calcification), in hypercalcemic or hyperparathyroid states (2).

What are the types of pathologic calcification?


  • Definition – Abnormal deposition of calcium salts in the tissue other than osteoid or enamel.
  • Two types of pathologic calcifications are-
  • Dystrophic calcification.
  • Metastatic calcification.

What causes pathologic calcification?

Causes of calcification infections. calcium metabolism disorders that cause hypercalcemia (too much calcium in the blood) genetic or autoimmune disorders affecting the skeletal system and connective tissues. persistent inflammation.

What is the difference between dystrophic and metastatic calcification?

Metastatic calcification with hypercalcemia occurs when calcium deposits in previously normal tissue whereas dystrophic calcification occurs in previously damaged tissue. (1) Dystrophic calcification in injured or necrotic tissue in a normal serum calcium level, such as tuberculosis, abscess, and hydatid disease.

What is pathological classification?

This classification is based on the clinico-pathological consequences of the blood pressure elevation. BENIGN (ESSENTIAL) HYPERTENSION. Often asymptomatic and discovered only during a routine medical examination.

What are the treatment of pathological calcification?

Dystrophic calcification is known as a condition that is difficult to treat. Various therapies have been tried. Pharmacological approaches include warfarin, colchicine, probenecid, bisphosphonates, and diltiazem, all of which have been used with variable success.

What calcification means?

Calcification is a process in which calcium builds up in body tissue, causing the tissue to harden. This can be a normal or abnormal process.

What is dystrophic calcification examples?

Examples of areas in the body where dystrophic calcification occurs include atherosclerotic plaques, damaged heart valves, and lymph nodes in the presence of tuberculosis infection.

What is dystrophic calcification in pathology?

Dystrophic calcification is deposition of calcium salt in degenerated tissues with the absence of a systemic mineral imbalance. It is often associated with trauma, infection, or inflammation and rarely appears in the head and neck area.

What is a pathologic diagnosis?

A pathologic diagnosis is the result of a complex series of activities, mastered by the pathologist. The nature of these activities is, however, rarely talked about in depth. The medical literature occasionally discusses aspects of the pathologic diagnosis processes, generally departing from the pathologic practice.

What are the clinical features of pathologic calcification?

Clinical features – Pathologic calcification dose not produce clinical dysfunction but massive depositions in organs can damage the organ (eg. Nephrocalcinosis producing renal damage) Dr.A.K.Mandal, Dr. Sharmana Choudhury. Textbook of Pathology.

What are the causes of calcification of dead tissue?

In dystrophic calcification Osteopontin is found in abundance resulting resulting in calcification of dead or degenerated tissue. Psammoma bodies in some tumors like papillary carcinoma thyroid/ Meningioma/ Papillary renal cell carcinoma/ Papillary serous cystadenoma.

What is the pathophysiology of dystrophic calcification of necrotic tissue?

Dystrophic calcification: Pathogenesis • Denatured proteins in necrotic or degenerated tissue bind phosphate ions, which react with calcium ions to form precipitates of calcium phosphate.

What is metastatic calcification?

Metastatic calcification • Calcification in normal tissue whenever there is hypercalcemia. • These may be due to• These may be due to – Excessive mobilisation of calcium from the bone – Excessive absorption of calcium from the gut www.facebook.com/notesdental