Which is pesticide 2,4-dinitrophenol?
2,4-Dinitrophenol is used in the manufacture of dyes, wood preservatives, and as a pesticide. The acute (short-term) effects of 2,4-dinitrophenol in humans through oral exposure are nausea, vomiting, sweating, dizziness, headaches, and loss of weight.
What is the common name of 2,4-dinitrophenol?
2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor….CHEBI:42017.
|2,4-DNP||NIST Chemistry WebBook|
What does DNP uncoupler do?
Dinitrophenol (DNP) is an uncoupler, or has the ability to separate the flow of electrons and the pumping of H+ ions for ATP synthesis. This means that the energy from electron transfer cannot be used for ATP synthesis. Fifty years ago, DNP was given as a drug to help patients lose weight.
What does dinitrophenol do to a cell?
In living cells, DNP acts as a proton ionophore, an agent that can shuttle protons (hydrogen cations) across biological membranes. It dissipates the proton gradient across mitochondria membranes, collapsing the proton motive force that the cell uses to produce most of its ATP chemical energy.
How does 2/4 dinitrophenol affect cellular respiration?
Mitochondrial uncouplers, such as 2,4 dinitrophenol (DNP), increase the cellular respiration by decreasing mitochondrial membrane potential (delta psi). We show that this respiratory effect can be transient or even prevented in isolated liver cells depending on the exogenous substrate used (dihydroxyacetone vs.
How does 2/4 dinitrophenol cause weight loss?
DNP (2,4-Dinitrophenol) has a variety of industrial uses, including as a photographic chemical, a fertilizer and in the manufacturing of dyes and explosives. It causes weight loss by burning fat and carbohydrates, in turn causing energy to be converted into heat.
Why 2/4 dinitrophenol would cause an increase in metabolism?
2-4-Dinitrophenol (DNP) was one of the first antiobesity therapy used in the 1930s. Its effect was first noticed among factory workers who were exposed to this and lost weight. It was shown to cause weight loss by uncoupling oxidative phosphorylation, leading to a heightened metabolic rate and increased fat metabolism.
How does 2/4 dinitrophenol uncouple oxidative phosphorylation?
Phosphorylating particles washed with 2,4-dinitrophenol lose coupling enzyme and with it the ability to form the energy-rich intermediate and to couple phosphorylation to electron transport.