Table of Contents
What are the four colony stimulating factors?
The colony stimulating factors (CSFs) comprise a small family of homodimeric cytokines central to blood formation, leukocyte function, and overall immune competence. Family members include macrophage-CSF (M-CSF), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin-3 (IL-3).
What causes colony-stimulating factor?
Granulocyte colony-stimulating factor is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant.
What are colony stimulating factors examples?
Colony stimulating factors circulate in the blood, acting as hormones, and are also secreted locally. An example is erythropoietin, which is produced in the kidney and regulates the formation of red blood cells from progenitor cells in the bone marrow. Colony-stimulating factors include CSF1, CSF2 and CSF3.
Which drugs are considered colony stimulating factors?
Granulocyte colony stimulating factor (G-CSF)
- lenograstim (Granocyte)
- filgrastim (Neupogen, Zarzio, Nivestim, Accofil)
- long acting (pegylated) filgrastim (pegfilgrastim, Neulasta, Pelmeg, Ziextenco) and lipegfilgrastim (Lonquex)
Are colony stimulating factors hormones?
The colony-stimulating factors (CSF) are a class of glycoprotein hormones that regulate the production and function of blood cells.
What is the functional importance of colony stimulating factors quizlet?
The main function of CSF (Colony Stimulating Factors) is: Increase the immune system by increasing the number of neutrophils produced.
What if neutrophils are high?
Having a high percentage of neutrophils in your blood is called neutrophilia. This is a sign that your body has an infection. Neutrophilia can point to a number of underlying conditions and factors, including: infection, most likely bacterial.
How can I increase my neutrophils naturally?
Eating foods rich in vitamins B9 or B12 or taking these as supplements may help improve low neutrophil blood levels. Examples of foods rich in vitamin B12 include: eggs….How to raise neutrophil levels
- colony-stimulating factors.
- corticosteroids.
- bone marrow or stem cell transplantation.
- antibiotics to help prevent infection.
What are the side effects of filgrastim?
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- Bleeding gums.
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
What causes neutropenic sepsis?
Neutropenic sepsis is commonly caused by bacterial infection with Gram-positive pathogens such as Staphylococcus aureus, Enterococcus sp, Streptococcus pneumoniae and S.
What is the function of colony?
In biology, a colony is composed of two or more conspecific individuals living in close association with, or connected to, one another. This association is usually for mutual benefit such as stronger defense or the ability to attack bigger prey.
What are colony-stimulating factors quizlet?
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.
What are the causes of colony stimulating factors?
Medical conditions associated with colony stimulating factors: Aplastic Anemia. Bone Marrow Transplantation. Bone Marrow Transplantation, Failure or Engraftment Delay.
What is colony stimulating factor (CSF)?
Colony-stimulating factor (CSF) is the operational term for a class of molecules that stimulate hematopoietic progenitor cells to divide and generate colonies of differentiated progeny such as neutrophils or macrophages.
What are the colonic stimulating factors?
Colony Stimulating Factors 1 Darbepoietin alfa (aranesp ®) 2 Erythropoietin (epogen ®) 3 Filgrastim (g-csf, neupogen ®, zarxio ™) 4 Oprelvekin (neumega ® ) 5 Pegfilgrastim (neulasta ®) 6 Peginesatide – omontys®
What are colony-stimulating factors in fungal infection?
Colony-stimulating factors (G-CSF, GM-CSF) reduce the duration and incidence of neutropenic fevers. In some studies these have decreased the incidence of fungal infections and early survival, although these findings have not been widely replicated. 140,141 Colony-stimulating factors may enhance the activity of antifungal agents.